Seebio Biotech. Inc

Papain

— Papain, papaya proteinase
Product Category: Plant Extractions
Sales Method: Export
Payment Term: T/T
Min. Order Unit Price
Contact Info

Mr.Aaron Liu

Address: China (mainland) Shanghai Shanghai,11-502 Lane 299, Bisheng Rd.

Product Detail

Product Attribute:

  • China (mainland) More >
  • 04/03/2012
  • 04/03/2012

Product Content Description:

Papain, also known as papaya proteinase I, is a cysteine protease (EC 3.4.22.2) enzyme present in papaya (Carica papaya) and mountain papaya (Vasconcellea cundinamarcensis).

Applications of Papain:
Pharmaceutical Industry
Food Industry
Beauty and Cosmetic Industry
Feeds Industry
Household Chemical Products
Leather Industry
Textile Industry

Papain belongs to a family of related proteins with a wide variety of activities, including endopeptidases, aminopeptidases, dipeptidyl peptidases and enzymes with both exo- and endo-peptidase activity.[1] Members of the papain family are widespread, found in baculovirus, eubacteria, yeast, and practically all protozoa, plants and mammals.The proteins are typically lysosomal or secreted, and proteolytic cleavage of the propeptide is required for enzyme activation, although bleomycin hydrolase is cytosolic in fungi and mammals. Papain-like cysteine proteinases are essentially synthesised as inactive proenzymes (zymogens) with N-terminal propeptide regions. The activation process of these enzymes includes the removal of propeptide regions, which serve a variety of functions in vivo and in vitro. The pro-region is required for the proper folding of the newly synthesised enzyme, the inactivation of the peptidase domain and stabilisation of the enzyme against denaturing at neutral to alkaline pH conditions. Amino acid residues within the pro-region mediate their membrane association, and play a role in the transport of the proenzyme to lysosomes. Among the most notable features of propeptides is their ability to inhibit the activity of their cognate enzymes and that certain propeptides exhibit high selectivity for inhibition of the peptidases from which they originate.

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